Aire is an important regulator of immunological tolerance operating in a minute subset of thymic stromal cells to induce transcripts encoding peptides that guideline T-cell selection. dystrophy) have a mutation in the gene encoding Aire. Such individuals and mice lacking Aire develop multi-organ autoimmune disease. Aire promotes immunological Cimigenol-3-O-alpha-L-arabinoside tolerance by inducing specifically in thymic… Continue reading Aire is an important regulator of immunological tolerance operating in a