The SBM mouse is a unique transgenic model of polycystic kidney disease (PKD) induced by the dysregulated expression of c-myc in renal tissue. displayed a markedly elevated (10C100-fold) apoptotic buy 1561178-17-3 index. However, no significant difference in bcl-2, bax, or p53 expression was observed in SBM kidney compared with controls. Direct proof that the heightened… Continue reading The SBM mouse is a unique transgenic model of polycystic kidney