Supplementary MaterialsSupp Information. the Comparative Toxicogenomics Database revealed that these p53 actives were significantly associated with improved manifestation of p53 downstream genes involved in DNA damage reactions. Furthermore, 53 chemical substructures associated with genotoxicity were enriched in certain classes of p53 actives, e.g., anthracyclines (antineoplastics) and vinca alkaloids (tubulin disruptors). Oddly enough, the tubulin disruptors… Continue reading Supplementary MaterialsSupp Information. the Comparative Toxicogenomics Database revealed that these p53
Tag: Rabbit Polyclonal to NSE
The major oncogenic driver of acute promyelocytic leukemia (APL) is the
The major oncogenic driver of acute promyelocytic leukemia (APL) is the fusion protein PML-RAR originated from the chromosomal translocation t(15;17). target both ATRA- sensitive and resistant APL cells through their distinct acting mechanism, and are potential drug leads for APL treatment.