Monoclonal antibodies directed against cytotoxic T lymphocyteCassociated antigen-4 (CTLA-4), such as for example ipilimumab, yield significant scientific benefit for individuals with metastatic melanoma by inhibiting immune system checkpoint activity, but scientific predictors of response to these therapies remain incompletely characterized. solid determinants of response and level of resistance to immune system checkpoint inhibitors. Blockade of… Continue reading Monoclonal antibodies directed against cytotoxic T lymphocyteCassociated antigen-4 (CTLA-4), such as
Tag: Rabbit polyclonal to PCDHB10
Background Heart transplantation is a lifesaving procedure for patients with end-stage
Background Heart transplantation is a lifesaving procedure for patients with end-stage heart failure. P2X7R targeting with periodate-oxidized ATP (oATP) promotes long-term cardiac transplant survival in 80% of murine recipients of a fully mismatched allograft. Long-term survival of cardiac transplants was associated with reduced T cell activation, Th1/Th17 differentiation and inhibition of STAT3 phosphorylation in T… Continue reading Background Heart transplantation is a lifesaving procedure for patients with end-stage