Although apoptosis occurs during myogenesis its mechanism of initiation remains unknown. activation of ER stress signaling was sufficient for induction of apoptosis. Activation of caspase-12 was also detected in developing muscle mass of mouse embryos and gradually disappeared later. CHOP was Irsogladine also transiently induced. These results suggest that specific ER stress signaling transmitted by… Continue reading Although apoptosis occurs during myogenesis its mechanism of initiation remains unknown.