Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus. in addition to its role as a precursor for p50 and cytoplasmic inhibitor of NF-B, p105 is usually a negative regulator of TPL-2. Insensitivity of C-terminally truncated TPL-2 to this regulatory mechanism is likely to contribute to its… Continue reading Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot)
Tag: Rabbit Polyclonal to RHG17
Open in another window strong course=”kwd-title” Keywords: Aurora-A, Imidazo[4,5- em b
Open in another window strong course=”kwd-title” Keywords: Aurora-A, Imidazo[4,5- em b /em ]pyridine, Aurora kinase Abstract Introduction of the 1-benzyl-1 em H /em -pyrazol-4-yl moiety in C7 from the imidazo[4,5- em b /em ]pyridine scaffold provided 7a which inhibited a variety of kinases including Aurora-A. substances exhibiting Aurora isoform selectivity are also reported including AZD1152… Continue reading Open in another window strong course=”kwd-title” Keywords: Aurora-A, Imidazo[4,5- em b