Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localization of the small GTPase RhoA at sites of cellCcell contact. or silencing 1 integrin. However, integrin manifestation levels are not refurbished by RhoA signaling inhibition. These data uncover a potential part for PKP2 upstream of 1 integrin and RhoA in integrating cellCcell and cellCsubstrate… Continue reading Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localization