NFB is regulated by an array of signaling cascades including glycogen synthase kinase (GSK) 3 and takes on a Janus part in podocyte damage. antiapoptotic/prosurvival element Bcl-xL and immune system/inflammatory mediators, like B7-1 and cathepsin L, which play a pivotal part in podocyte damage by disrupting podocyte cytoskeleton13. Actin cytoskeleton disorganization continues to be centrally… Continue reading NFB is regulated by an array of signaling cascades including glycogen