The methylation of specific lysine residues in histone H3 is integral to transcription regulation; however little is known about how combinations of methylated lysine residues act in concert to regulate genome-wide transcription. and then spreads into the chromosome. This effect is mediated by the silent information regulator (SIR) silencing complex as we observe increased binding… Continue reading The methylation of specific lysine residues in histone H3 is integral