Hypoxic environment is crucial in colorectal cancer (CRC) development. in addition to the transcriptional activity of HIF-31. Nevertheless, the inhibition from the upstream regulator Janus kinase (JAK) abolished HIF-31-induced p-STAT3 and cell development. Together, these outcomes proven that HIF-31 promotes CRC cell development by activation from the JAK-STAT3 signaling pathway through non-canonical transcription-independent systems. (and… Continue reading Hypoxic environment is crucial in colorectal cancer (CRC) development. in addition