Background Therapy level of resistance remains 1 of the main problems to improve the treatment of sufferers with pancreatic tumor. Bottom line a SP was identified by us in individual PDAC and uncovered a chemoresistant and CSC-associated phenotype. This SP might represent a new therapeutic target in pancreatic cancer. Trial enrollment Clinicaltrials.gov “type”:”clinical-trial”,”attrs”:”text”:”NCT00936104″,”term_id”:”NCT00936104″NCT00936104 in these… Continue reading Background Therapy level of resistance remains 1 of the main problems
Tag: SB-207499
Background Lack of ability of heart failure (HF) patients to recognize
Background Lack of ability of heart failure (HF) patients to recognize worsening symptoms that herald an exacerbation is a common reason for HF readmissions. less variable revealed worse event-free survival in patients with more variable symptoms of shortness of breath or edema. Symptom variability predicted event-free survival independently of severity of symptoms ejection fraction comorbidities… Continue reading Background Lack of ability of heart failure (HF) patients to recognize
Mutations in the coding region of hepatocyte nuclear factor 4α (HNF4α)
Mutations in the coding region of hepatocyte nuclear factor 4α (HNF4α) and its upstream promoter (P2) that drives expression in the pancreas are known to lead to maturity-onset diabetes of the small 1 (MODY1). mice. Because insulin increases the activity SB-207499 of sterol regulatory element-binding proteins (SREBP)-1c and -2 we also examined the effect of… Continue reading Mutations in the coding region of hepatocyte nuclear factor 4α (HNF4α)