We tested the classical hypothesis that astral prometaphase bipolar mitotic spindles are maintained by balanced outward and inward makes exerted on spindle poles by kinesin-5 and -14 using modeling of in vitro and in vivo data from embryos. incorporating motor kinetics and load-dependent detachment. Motor parameters from this model were applied to a new stochastic… Continue reading We tested the classical hypothesis that astral prometaphase bipolar mitotic spindles