Glutamate may be the main excitatory neurotransmitter in the mammalian CNS and serves on both ionotropic and metabotropic glutamate receptors (mGluRs). CaM competes with Siah-1A for mGluR5 binding within a phosphorylation-dependent way in rat hippocampal neurons. Phosphorylation of mGluR5 S901 mementos Siah-1A binding by displacing CaM Specifically. We identified important residues regulating Siah-1A binding to… Continue reading Glutamate may be the main excitatory neurotransmitter in the mammalian CNS