Aberrant cellular responses to pro-inflammatory cytokines, such as IFN-, are pathogenic features in many chronic inflammatory diseases. upregulation of KSRP destabilizes CX3CL1 mRNA, providing fine-tuning of cellular inflammatory reactions in response to IFN- excitement. The inflammatory response is definitely a double-edged sword, as excessive swelling itself can exacerbate cells damage1,2. Chronic swelling and cellular injury… Continue reading Aberrant cellular responses to pro-inflammatory cytokines, such as IFN-, are pathogenic
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We’ve investigated the mutagenicity induced in the locus in Chinese hamster
We’ve investigated the mutagenicity induced in the locus in Chinese hamster ovary (CHO) cells treated with increasing concentrations of Me-lex, a minor groove selective methylating agent that efficiently generates more than 90-95% of 3-MeA DNA adducts. result in recombination and genomic deletions, therefore representing a severe threat for genome integrity. and in mammalian cells, and… Continue reading We’ve investigated the mutagenicity induced in the locus in Chinese hamster